Anti-CD154 (CD40L) Mouse Monoclonal Antibody [clone: 5C8] (APC)

Lieferant: STEMCELL Technologies
100-1350
STMC100-1350EA 818 EUR
STMC100-1350
Anti-CD154 (CD40L) Mouse Monoclonal Antibody [clone: 5C8] (APC)
Antikörper
Mouse monoclonal antibody against human CD154 (CD40L).

  • T cells

This mouse monoclonal antibody (clone 5C8, APC-conjugated) reacts with human CD154 (CD40L), a member of the TNF-α superfamily with a molecular weight of 39 kDa. CD154, also known as CD40L, gp39, TRAP, and T-BAM, is a type II transmembrane glycoprotein that is predominantly expressed on activated T-cells, but is also found in NK cells, mast cells, basophils, and eosinophils. CD154 (CD40L) binds to CD40, a costimulatory protein found on antigen-presenting cells, such as B cells, monocytes, dendritic cells, and fibroblasts. The CD154 (CD40)-CD40L interaction induces the activation and proliferation of B-cells, allowing for antibody production, isotype switching, and B-cell memory development. Use this monoclonal antibody in applications requiring detection of CD154/CD40L such as flow cytometry (FC). CD154 (CD40L) expression is upregulated in inflammatory bowel disease, suggesting its role in regulating pathogenic cytokine production in T-cells. In vitro studies also demonstrate that the binding of CD40 to its ligand induces endothelial cell activation in vitro, highlighting the immunopathogenic role that CD40 and its ligand plays. The CD154 (CD40L), clone 5C8 antibody has been reported to block the interaction and ligation of CD40 with its ligand.

Bitte beachten Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD154 (CD40L)
Clonality: Monoclonal
Clone: 5C8
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human
Bestellen

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Mehr About VWR