Anti-CD49f Rat Monoclonal Antibody [clone: GoH3] (APC)

Lieferant: STEMCELL Technologies
STMC60037AZEA 606 EUR
STMC60037AZ STMC60037AZ.1
Anti-CD49f Rat Monoclonal Antibody [clone: GoH3] (APC)
Antikörper
Rat monoclonal IgG2a antibody against human, mouse, rhesus CD49f, APC-conjugated.

  • Mammary cells

The GoH3 antibody reacts with CD49f, an ~150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin β1) or CD104 (integrin β4) to form the heterodimeric receptors VLA-6 and α6β4, which bind the extracellular matrix protein laminin. CD49f is a disulfide-linked dimer comprising an ~120 kDa heavy chain and an ~30 kDa membrane-bound light chain. Splice variants exist, which affect the cytoplasmic domain of the protein. CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial cells, and endothelial cells. It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of stem cell pluripotency. CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells. The GoH3 antibody reacts with an extracellular epitope on CD49f and reportedly blocks integrin α6 function in vivo and binding of integrin α6 to laminin in vitro.

Bitte beachten Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD49f
Clonality: Monoclonal
Clone: GoH3
Conjugation: APC
Epitope:
Host: Rat
Isotype: IgG2a kappa
Reactivity: Baboon, Capuchin monkey, Cat, Chimpanzee, Bovine, Cynomolgus monkey, Dog, Horse, Human, Mouse, Pig, Rabbit, Rhesus monkey, Sheep
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