Anti-CD56 (NCAM) Mouse Monoclonal Antibody [clone: HCD56] (Alexa Fluor® 488)

Lieferant: STEMCELL Technologies
60021AD 60021AD.1
STMC60021ADEA 533 EUR
STMC60021AD STMC60021AD.1
Anti-CD56 (NCAM) Mouse Monoclonal Antibody [clone: HCD56] (Alexa Fluor® 488)
Antikörper
Mouse monoclonal IgG1 antibody against human CD56 (NCAM), Alexa Fluor® 488-conjugated.

  • Nk cells

The HCD56 antibody reacts with CD56 (NCAM), a member of the immunoglobulin (Ig) super family containing 5 Ig-like domains and two fibronectin type-3 domains in its extracellular portion. Multiple isoforms have been identified, including transmembrane and GPI-anchored forms. CD56 is subject to several types of post-translational modification, including addition of a polysialic acid moiety to the 5th Ig-like domain. The ~140 kDa isoform of CD56 is considered the prototypic cell surface marker on human NK cells. Around 90% of the NK cells express CD56 at low density while ~10% express the protein at relatively high levels. CD56 is also variably expressed by a subset of NK-T cells in peripheral blood, neurons, muscle cells, some stem cells, and in vitro-cultured T cell clones. It is also expressed by several types of tumors, including myeloma, neuroblastoma and small cell lung carcinoma cells. CD56 mediates cell-cell and cell-matrix adhesion via homophilic and heterophilic interactions, respectively, and has been implicated in activating intracellular signaling pathways. CD56 plays important roles in neuronal development both during embryogenesis and in adults. This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ HLA Buffy Coat CD56 Positive Selection Kit (Catalog #18085HLA) and EasySep™ Human CD56 Positive Selection Kit (Catalog #18055); partial blocking may be observed, as well as EasySep™ HLA CD2 Positive Selection Kit (Catalog #18657HLA) and EasySep™ Human NK Cell Enrichment Kit (Catalog #19055).

Bitte beachten Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD56 (NCAM)
Clonality: Monoclonal
Clone: HCD56
Conjugation: Alexa Fluor® 488
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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