Anti-CD41 Mouse Monoclonal Antibody [clone: HIP8] (APC)

Lieferant: STEMCELL Technologies
STMC60114AZ.1EA 285 EUR
STMC60114AZ.1 STMC60114AZ
Anti-CD41 Mouse Monoclonal Antibody [clone: HIP8] (APC)
Antikörper
Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD41, APC-conjugated.

  • Megakaryocytes
  • Platelets

The HIP8 antibody reacts with the ~125 kDa GPIIbα subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes, and acute megakaryoblastic leukemia cells. The GPIIbα subunit is linked to a smaller ~25 kDa subunit (GPIIbβ) by a single disulfide bond. Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells. CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41/CD61 (or GPIIb/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin, and thrombin. Binding to the CD41/CD61 complex involves an RGD tripeptidyl sequence in the ligand, and both ligand occupancy and ligand-mediated receptor clustering are functionally important in the integrin-mediated response. The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds.

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Type:
Antigen: CD41
Clonality: Monoclonal
Clone: HIP8
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Baboon, Capuchin monkey, Chimpanzee, Cynomolgus monkey, Human, Pig, Rhesus monkey
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