Mouse monoclonal IgM antibody against human, mouse, rat SSEA-1 (CD15), PE-conjugated.
The MC-480 antibody reacts with a terminal carbohydrate epitope, stage-specific embryonic antigen-1 (SSEA-1), which is expressed on a large-molecular-mass (>200 kDa) glycoprotein on the surface of early mouse embryos, mouse embryonal carcinoma (EC), embryonic stem (ES) cells and mouse and human embryonic germ (EG) cells. SSEA-1 is not expressed on undifferentiated human EC, ES or induced pluripotent stem (iPS) cells, or rhesus monkey ES cell lines. Its expression on mouse ES cells is decreased upon differentiation, whereas in humans, expression is upregulated during differentiation. SSEA-1 is also found on adult human granulocytes and monocytes, where it is denoted CD15, and the MC-480 antibody recognizes the CD15 marker on these cell types. It has been reported that SSEA-1 has roles in cell adhesion and migration, and regulation of cell differentiation. This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ HLA Whole Blood CD15 Positive Selection Kit (Catalog #18681HLA; partial blocking may be observed), and for labeling human ES and iPS cells grown in TeSR™-E8™ (Catalog #05940), mTeSR™1 (Catalog #85850) and TeSR™2 (Catalog #05860).
Bitte beachten Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').
Type:
Antigen: SSEA-1 (CD15)
Clonality: Monoclonal
Clone: MC-480
Conjugation: PE
Epitope:
Host: Mouse
Isotype: IgM kappa
Reactivity: Human, Mouse, Rat