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Image Unavailable-CAYM17276-1

IKK Inhibitor VI ≥95%

Lieferant: Cayman Chemical
Beschreibung: IKK Inhibitor VI ≥95%

Image Unavailable-ENZOBMLP6070500

IKK-NBD peptide

Artikel-Nr: (ENZOBMLP6070500)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: NF-kappaB inhibitor
VE: 1 * 0,5 mg

Neuer Artikel bei VWR!


Image Unavailable-ENZOBMLEI3430050

SC-514 ≥98% (durch TLC)

Lieferant: ENZO LIFE SCIENCES
Beschreibung: IKK inhibitor

Neuer Artikel bei VWR!

Image Unavailable-ENZOBMLEI3160001

Wedelolactone ≥98% (durch TLC)

Artikel-Nr: (ENZOBMLEI3160001)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: IKK inhibitor
VE: 1 * 1 mg

Neuer Artikel bei VWR!


Image Unavailable-ENZOENZCHM1890005

BX-795 ≥97% (durch HPLC)

Lieferant: ENZO LIFE SCIENCES
Beschreibung: Inhibitor of PDK1, TBK1, IKK-ε, IRF3

Neuer Artikel bei VWR!

Image Unavailable-BOSSBS-3232R-A750

Anti-IKK beta Tyr199 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-3232R-A750)
Lieferant: Bioss
Beschreibung: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-3232R-A647

Anti-IKBKB Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Artikel-Nr: (BOSSBS-3232R-A647)
Lieferant: Bioss
Beschreibung: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-3232R-A555

Anti-IKBKB Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-3232R-A555)
Lieferant: Bioss
Beschreibung: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-3232R-CY7

Anti-IKBKB Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-3232R-CY7)
Lieferant: Bioss
Beschreibung: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-3228R-A750

Anti-IKK gamma Ser31 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-3228R-A750)
Lieferant: Bioss
Beschreibung: Pro inflammatory cytokines activate the transcription factor NF kappa B by stimulating the activity of a protein kinase that phosphorylates Ikappa B, an inhibitor of NF kappa B, at sites that trigger its ubiquitination and degradation. A large, cytokine responsive Ikappa B kinase (IKK) complex has been purified and the genes encoding 2 of its subunits have been cloned. These subunits, IKK alpha and Ikk beta, are protein kinases whose function is needed for NF kappa B activation by pro inflammatory stimuli. IKK is composed of similar amounts of IKK alpha, Ikk beta, which are differentially processed forms of a third subunit, IKK gamma. IKK gamma interacts preferentially with IKK beta and is required for the activation of the IKK complex.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-3232R-A680

Anti-IKK beta Tyr199 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Artikel-Nr: (BOSSBS-3232R-A680)
Lieferant: Bioss
Beschreibung: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-6202R-CY5.5

Anti-TRAF3IP2 Rabbit Polyclonal Antibody (Cy5.5®)

Artikel-Nr: (BOSSBS-6202R-CY5.5)
Lieferant: Bioss
Beschreibung: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-6202R-CY7

Anti-TRAF3IP2 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-6202R-CY7)
Lieferant: Bioss
Beschreibung: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-3228R-CY5.5

Anti-IKBKG Rabbit Polyclonal Antibody (Cy5.5®)

Artikel-Nr: (BOSSBS-3228R-CY5.5)
Lieferant: Bioss
Beschreibung: Pro inflammatory cytokines activate the transcription factor NF kappa B by stimulating the activity of a protein kinase that phosphorylates Ikappa B, an inhibitor of NF kappa B, at sites that trigger its ubiquitination and degradation. A large, cytokine responsive Ikappa B kinase (IKK) complex has been purified and the genes encoding 2 of its subunits have been cloned. These subunits, IKK alpha and Ikk beta, are protein kinases whose function is needed for NF kappa B activation by pro inflammatory stimuli. IKK is composed of similar amounts of IKK alpha, Ikk beta, which are differentially processed forms of a third subunit, IKK gamma. IKK gamma interacts preferentially with IKK beta and is required for the activation of the IKK complex.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-3228R-HRP

Anti-IKBKG Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Artikel-Nr: (BOSSBS-3228R-HRP)
Lieferant: Bioss
Beschreibung: Pro inflammatory cytokines activate the transcription factor NF kappa B by stimulating the activity of a protein kinase that phosphorylates Ikappa B, an inhibitor of NF kappa B, at sites that trigger its ubiquitination and degradation. A large, cytokine responsive Ikappa B kinase (IKK) complex has been purified and the genes encoding 2 of its subunits have been cloned. These subunits, IKK alpha and Ikk beta, are protein kinases whose function is needed for NF kappa B activation by pro inflammatory stimuli. IKK is composed of similar amounts of IKK alpha, Ikk beta, which are differentially processed forms of a third subunit, IKK gamma. IKK gamma interacts preferentially with IKK beta and is required for the activation of the IKK complex.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-3228R-FITC

Anti-IKBKG Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Artikel-Nr: (BOSSBS-3228R-FITC)
Lieferant: Bioss
Beschreibung: Pro inflammatory cytokines activate the transcription factor NF kappa B by stimulating the activity of a protein kinase that phosphorylates Ikappa B, an inhibitor of NF kappa B, at sites that trigger its ubiquitination and degradation. A large, cytokine responsive Ikappa B kinase (IKK) complex has been purified and the genes encoding 2 of its subunits have been cloned. These subunits, IKK alpha and Ikk beta, are protein kinases whose function is needed for NF kappa B activation by pro inflammatory stimuli. IKK is composed of similar amounts of IKK alpha, Ikk beta, which are differentially processed forms of a third subunit, IKK gamma. IKK gamma interacts preferentially with IKK beta and is required for the activation of the IKK complex.
VE: 1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das call noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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