Sie suchten nach: Tonbo Biosciences

Lieferant: Tonbo Biosciences

Beschreibung: The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will "compete" for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.

Artikel-Nr: (25-4724-U100)

Lieferant: Tonbo Biosciences

Beschreibung: The C1.18.4 immunoglobulin is useful as an isotype-matched control. The C.1.18.4 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2a antibodies.

VE: 1 * 100 µG

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Artikel-Nr: (30-8077-M002)

Lieferant: Tonbo Biosciences

Beschreibung: Rabbit anti-Mouse IgG (H&L) - Affinity Pure, Biotin Conjugate, min x w/human serum proteins

VE: 1 * 2 mg

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Artikel-Nr: (70-8028-M002)

Lieferant: Tonbo Biosciences

Beschreibung: Goat anti-Human IgM (mu chain) - Affinity Pure

VE: 1 * 2 mg

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Artikel-Nr: (30-8016-M001)

Lieferant: Tonbo Biosciences

Beschreibung: Goat anti-Human IgA (alpha chain) - Affinity Pure, Biotin Conjugate

VE: 1 * 1 mg

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Artikel-Nr: (30-8030-M001)

Lieferant: Tonbo Biosciences

Beschreibung: Goat anti-Human IgM (mu chain) - Affinity Pure, Biotin Conjugate, min x w/human IgA + IgG

VE: 1 * 1 mg

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Artikel-Nr: (72-8114-M001)

Lieferant: Tonbo Biosciences

Beschreibung: Goat anti-Mouse IgG Fc - Affinity Pure, HRP Conjugate

VE: 1 * 1 mg

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Artikel-Nr: (72-8110-M001)

Lieferant: Tonbo Biosciences

Beschreibung: Goat anti-Rabbit IgG Fc - Affinity Pure, HRP Conjugate

VE: 1 * 1 mg

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Artikel-Nr: (40-4801-U100)

Lieferant: Tonbo Biosciences

Beschreibung: The BM8.1 antibody is specific for mouse F4/80 antigen, a 125 kDa transmembrane protein widely expressed by members of the mononuclear phagocyte system and considered to be a key marker for mature macrophage cells. F4/80 is differentially expressed during myeloid cell development, and may be regulated by certain cytokines within the tissue microenvironment. Other cell types shown to express this antigen include Langerhans cells, Kupffer cells and dendritic cell subsets. BM8.1 is widely used together with antibodies to CD115 (c-fms), CD11b and CD11c to identify myeloid/ macrophage cells by flow cytometry.

VE: 1 * 100 µG

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Lieferant: Tonbo Biosciences

Beschreibung: The RB6-8C5 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.

Artikel-Nr: (40-4301-U100)

Lieferant: Tonbo Biosciences

Beschreibung: The HRPN immunoglobulin is useful as an isotype-matched control. The HRPN immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG1 antibodies.

VE: 1 * 100 µG

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Artikel-Nr: (60-4321-U100)

Lieferant: Tonbo Biosciences

Beschreibung: The 2A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2a antibodies.

VE: 1 * 100 µG

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Lieferant: Tonbo Biosciences

Beschreibung: The 2, 43 antibody reacts with the 32 to 34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death in tumor cells, as well as in cells infected by virus, bacteria or parasites.

Artikel-Nr: (75-4321-U100)

Lieferant: Tonbo Biosciences

Beschreibung: The 2A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2a antibodies.

VE: 1 * 100 µG

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Lieferant: Tonbo Biosciences

Beschreibung: The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.

Lieferant: Tonbo Biosciences

Beschreibung: The 15.2 antibody reacts with human CD54, also known as ICAM-1 (Intercellular Adhesion Molecule 1), a 90 to 110 kDa cell surface glycoprotein that is inducibly expressed on both immune and endothelial cells. As its name implies, ICAM-1 participates in cell-cell adhesion between leukocytes and endothelial cells, facilitating leukocyte recruitment and transmigration at sites of inflammation. The ligands for ICAM-1 are also expressed on leukocyte and endothelial cells, and include Mac-1, fibrinogen, and a member of the integrin protein family, LFA-1 (CD11a).