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Image Unavailable-AATB2116

7.1 CPG [TQ7.1 CPG], Tide Quencher™ (500 A)

Artikel-Nr: (AATB2116)
Lieferant: AAT BIOQUEST INC
Beschreibung: Tide Quencher™ 7.1 (TQ7.1) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750.
VE: 1 * 100 mg

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Image Unavailable-AATB2117

7.1 CPG [TQ7.1 CPG], Tide Quencher™ 1000 Å

Artikel-Nr: (AATB2117)
Lieferant: AAT BIOQUEST INC
Beschreibung: Tide Quencher™ 7.1 (TQ7.1) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750.
VE: 1 * 100 mg

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Product Image-PRSI25-590

Anti-MBD3 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI25-590)
Lieferant: ProSci Inc.
Beschreibung: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE: 1 * 50 µG
Product Image-558-0195

Verbrauchsmaterial für Agilent Technologies Autosampler

Lieferant: SGE Analytical Science
Beschreibung: Autosampler-Spritzen für HP7673, 7683, 7693A und 6850ALS.

Image Unavailable-APOSBIMN2051-1G

FAM-CPG

Artikel-Nr: (APOSBIMN2051-1G)
Lieferant: Apollo Scientific
Beschreibung: FAM-CPG
VE: 1 * 1 g
Image Unavailable-ENZOALX746056M001

ODN 2006 (Type B) (synthetisch), TLRgrade™

Artikel-Nr: (ENZOALX746056M001)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: CpG oligodeoxynucleotide (Type B) with phosphorothioate backbone. Specific ligand for human and mouse TLR9 (Toll-like receptor 9).
VE: 1 * 1 mg

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Image Unavailable-H62838.MD

N-Boc-2-cyclopentyl-L-glycine dicyclohexylammonium salt 95%

Artikel-Nr: (H62838.MD)
Lieferant: Thermo Scientific
Beschreibung: N-Boc-2-cyclopentyl-L-glycine dicyclohexylammonium salt 95%
VE: 1 * 250 mg

Zertifikate


Product Image-USBI038309-FITC

Anti-MECP2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Artikel-Nr: (USBI038309-FITC)
Lieferant: US Biological
Beschreibung: Anti-MECP2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
VE: 1 * 200 µl
Image Unavailable-BOSSBS-13025R-A555

Anti-TRDMT1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-13025R-A555)
Lieferant: Bioss
Beschreibung: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-13025R-A647

Anti-TRDMT1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Artikel-Nr: (BOSSBS-13025R-A647)
Lieferant: Bioss
Beschreibung: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
VE: 1 * 100 µl
Image Unavailable-USBI038240-APC

Anti-MBD4 Rabbit Polyclonal Antibody (APC (Allophycocyanin))

Artikel-Nr: (USBI038240-APC)
Lieferant: US Biological
Beschreibung: Anti-MBD4 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
VE: 1 * 200 µl
Product Image-USBI038232-BIOTIN

Anti-MBD2 Rabbit Polyclonal Antibody (Biotin)

Artikel-Nr: (USBI038232-BIOTIN)
Lieferant: US Biological
Beschreibung: Anti-MBD2 Rabbit Polyclonal Antibody (Biotin)
VE: 1 * 200 µl
Product Image-USBI038241-BIOTIN

Anti-MBD4 Rabbit Polyclonal Antibody (Biotin)

Artikel-Nr: (USBI038241-BIOTIN)
Lieferant: US Biological
Beschreibung: Anti-MBD4 Rabbit Polyclonal Antibody (Biotin)
VE: 1 * 200 µl
Image Unavailable-BOSSBS-5915R-CY3

Anti-MBD1 Rabbit Polyclonal Antibody (Cy3®)

Artikel-Nr: (BOSSBS-5915R-CY3)
Lieferant: Bioss
Beschreibung: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-5915R-CY5

Anti-MBD1 Rabbit Polyclonal Antibody (Cy5®)

Artikel-Nr: (BOSSBS-5915R-CY5)
Lieferant: Bioss
Beschreibung: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
VE: 1 * 100 µl
Image Unavailable-BSENM-1809-100

Anti-MECP2 Mouse Monoclonal Antibody [clone: 4F11]

Artikel-Nr: (BSENM-1809-100)
Lieferant: Biosensis
Beschreibung: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). Ref: uniprot.org
VE: 1 * 100 µG
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das call noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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