Sie suchten nach: GSK-2801

Artikel-Nr: (ACRO468031000)

Lieferant: Thermo Scientific

Beschreibung: Chemical probes can be used to help establish the
relationship between a molecular target and the broader
biological consequences of modulating that target in cells
or organisms.

VE: 1 * 100 mg

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Artikel-Nr: (630-2807)

Lieferant: MOTIC

Beschreibung: Diese aufrechten Mikroskope wurden für Schulungszwecke konzipiert.

VE: 1 * 1 ST

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Lieferant: ENZO LIFE SCIENCES

Beschreibung: Potent inhibitor of GSK-3 ATP-binding site.

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Artikel-Nr: (ENZOENZCHM1340005)

Lieferant: ENZO LIFE SCIENCES

Beschreibung: Cell-permeable, potent and selective GSK-3β inhibitor.

VE: 1 * 5 mg

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Artikel-Nr: (CAYM10009374-1)

Lieferant: Cayman Chemical

Beschreibung: Anti-GSK-3-beta Rabbit Polyclonal Antibody

VE: 1 * 1 ST

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Lieferant: ENZO LIFE SCIENCES

Beschreibung: Inibitor of phosphoinositide-dependent kinase 1 and GSK

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Artikel-Nr: (PRSI10-790)

Lieferant: ProSci Inc.

Beschreibung: Anti-GSK-2398852 Recombinant Antibody

VE: 1 * 0,1 mg

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Artikel-Nr: (PRSI10-755)

Lieferant: ProSci Inc.

Beschreibung: Anti-GSK-249320 Recombinant Antibody

VE: 1 * 0,1 mg

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Artikel-Nr: (68082-5G)

Lieferant: Merck

Beschreibung: Derivatisation reagent for HPLC separation of free fatty acids (FFAs) in human plasma, for liquid chromatography-UV-tandem mass spectrometric analysis of perfluorinated carboxylic acids.

VE: 1 * 5 g

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Artikel-Nr: (VWRS5640.0010)

Lieferant: VWR Collection

Beschreibung: GSK Eimer weiß PP 3,2 L + LID [10X]

VE: 1 * 10 ST

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Lieferant: ENZO LIFE SCIENCES

Beschreibung: Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.

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Artikel-Nr: (ENZOADI905762100)

Lieferant: ENZO LIFE SCIENCES

Beschreibung: Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI10-584)

Lieferant: ProSci Inc.

Beschreibung: Anti-GSK-1223249 Recombinant Antibody

VE: 1 * 0,1 mg

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Artikel-Nr: (ENZOALX350294M001)

Lieferant: ENZO LIFE SCIENCES

Beschreibung: GSK-3 inhibitor

VE: 1 * 1 mg

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Artikel-Nr: (ENZOALX270424M001)

Lieferant: ENZO LIFE SCIENCES

Beschreibung: Inhibitor of GSK and CDK/cyclin

VE: 1 * 1 mg

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Artikel-Nr: (BOSSBS-12435R-HRP)

Lieferant: Bioss

Beschreibung: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

VE: 1 * 100 µl

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