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CDK1/2 Inhibitor III ≥95% (durch HPLC)

Artikel-Nr: (ENZOALX270442M001)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: Cell permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC50=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3β (IC50=32nM and 140nM).
VE: 1 * 1 mg

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NU 2058

Artikel-Nr: (ENZOALX270394M025)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: Competitive inhibitor of CDK1/cyclin B (IC50=5µM) and CDK2/cyclin A (IC50=12µM). Pharmacologically distinct from the relative specific inhibitor of CDK1/2 roscovitine.
VE: 1 * 25 mg

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Image Unavailable-ENZOALX350293M001

(S)-Roscovitine ≥98% (durch HPLC)

Artikel-Nr: (ENZOALX350293M001)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: CDK1 inhibitor
VE: 1 * 1 mg

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Image Unavailable-ENZOALX270396M005

Olomoucine II ≥98% (durch HPLC)

Artikel-Nr: (ENZOALX270396M005)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: Selective inhibitor of CDK1/cyclin B (IC50=20nM). Potent cytotoxin in tumor cells: IC50=5.3µM against MCF7 cells, IC50=11.1µM against K562 cells, IC50=3.0µM against CEM cells, IC50=6.3µM against HOS cells, and IC50=6.3µM against G361 cells.
VE: 1 * 5 mg

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CGP 74514A

Artikel-Nr: (ENZOALX270391M005)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: Cell permeable, potent and selective inhibitor of CDK1/cyclin B (IC50=25 nm). Reported to affect the activities of other kinases only at much higher concentrations: PKCα (IC50=6.1 nm), PKA (IC50=125 µm) and EGFR (IC50>10 µm). Induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3 µm).
VE: 1 * 5 mg

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Indirubin-3'-oxime ≥98%

Lieferant: ENZO LIFE SCIENCES
Beschreibung: A potent inhibitor of glycogen synthase kinase-3β (IC50=22 nM). Also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM). It reversibly arrests asynchronous HBL-100 cells at G2. Induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM).

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Image Unavailable-ENZOALX270246M005

Purvalanol A ≥99% (durch NMR)

Lieferant: ENZO LIFE SCIENCES
Beschreibung: Inhibitor of human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well as CDK5/p35 (IC50=75nM). More membrane permeable than purvalanol B.

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Image Unavailable-ENZOALX270296M001

Indirubin-5-sulphonic acid sodium salt

Artikel-Nr: (ENZOALX270296M001)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: Inhibitor of cyclin-dependent kinases (CDKs), with selectivity for CDK1/cyclin B (IC50=55 nm), CDK2/cyclin A (IC50=35 nm), CDK2/cyclin E (IC50=150 nm), CDK4/cyclin D1 (IC50=300 nm), CDK5/p35 (IC50=65 nm) and GSK-3β (IC50=280 nm).
VE: 1 * 1 mg

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GW5074 ≥98% (durch TLC)

Lieferant: ENZO LIFE SCIENCES
Beschreibung: Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

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SU 9516 ≥95% (durch HPLC)

Artikel-Nr: (ENZOALX270400M005)
Lieferant: ENZO LIFE SCIENCES
Beschreibung: Cell permeable, potent, selective and ATP-competitive inhibitor of CDK2/cyclin A (IC50=22nM), CDK1/cyclin B (IC50=40nM) and CDK4/cyclin D1 (IC50=200nM). Has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10µM). Displays anti-proliferative and pro-apoptotic properties in tumor cells. Inhibits proliferation of growth factor-stimulated colon carcinoma cells by binding to CDK2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.
VE: 1 * 5 mg

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Image Unavailable-BOSSBS-5277R-CY5

Anti-CDK2 Rabbit Polyclonal Antibody (Cy5®)

Artikel-Nr: (BOSSBS-5277R-CY5)
Lieferant: Bioss
Beschreibung: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. cdk2 is a cell cycle protein closely related to Cdc2 (cdk1) that has proved useful as a marker of proliferation. cdk2 binds cyclin type A and E proteins and controls progression into S-phase.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-5277R-CY3

Anti-CDK2 Rabbit Polyclonal Antibody (Cy3®)

Artikel-Nr: (BOSSBS-5277R-CY3)
Lieferant: Bioss
Beschreibung: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. cdk2 is a cell cycle protein closely related to Cdc2 (cdk1) that has proved useful as a marker of proliferation. cdk2 binds cyclin type A and E proteins and controls progression into S-phase.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-5277R-A350

Anti-CDK2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Artikel-Nr: (BOSSBS-5277R-A350)
Lieferant: Bioss
Beschreibung: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. cdk2 is a cell cycle protein closely related to Cdc2 (cdk1) that has proved useful as a marker of proliferation. cdk2 binds cyclin type A and E proteins and controls progression into S-phase.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-5277R-CY7

Anti-CDK2 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-5277R-CY7)
Lieferant: Bioss
Beschreibung: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. cdk2 is a cell cycle protein closely related to Cdc2 (cdk1) that has proved useful as a marker of proliferation. cdk2 binds cyclin type A and E proteins and controls progression into S-phase.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-5277R-FITC

Anti-CDK2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Artikel-Nr: (BOSSBS-5277R-FITC)
Lieferant: Bioss
Beschreibung: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. cdk2 is a cell cycle protein closely related to Cdc2 (cdk1) that has proved useful as a marker of proliferation. cdk2 binds cyclin type A and E proteins and controls progression into S-phase.
VE: 1 * 100 µl
Image Unavailable-BOSSBS-5277R-A488

Anti-CDK2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-5277R-A488)
Lieferant: Bioss
Beschreibung: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. cdk2 is a cell cycle protein closely related to Cdc2 (cdk1) that has proved useful as a marker of proliferation. cdk2 binds cyclin type A and E proteins and controls progression into S-phase.
VE: 1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das call noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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